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Yes, it can be slightly unpleasant and painful, but it is only a minor inconvenience

Alternatively, if the elevated anion gap persists despite cessation of acetaminophen and administration of N-acetylcysteine, pyroglutamic acidosis is unlikely, and an alternative diagnosis should be sought

2012), whose susceptibility to APAP-induced hepatotoxicity is less than that of the mouse, but is still a commonly used animal model